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Contraindicated. CYP3A4 is chargeable for the formation and elimination of cariprazine's active metabolites. The effect of CYP3A4 inducers on cariprazine exposure has not been evaluated along with the net impact is unclear.pentobarbital will reduce the level or influence of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 me

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